TOC (Total Organic Carbon)
Total organic carbon (TOC) is the amount of carbon found in an organic compound and is often used as a non-specific indicator of water quality or cleanliness of pharmaceutical and manufacturing equipment.
Hy Laboratories is equipped with the new OI Analytica’s Aurora 1030W TOC Analyzer for the detection of total organic carbon (TOC) to provide you with the right solution for your TOC need. The system is fully automatic and using heated persulfate oxidation technology to detect TOC in a 0.5-30,000ppm range. The Aurora supports USEPA approved methods: USP <643> methods EU 22.44, 23 and complies with the GMP regulation. Hy Laboratories labs are certified GMP, ISRAC (ISO17025), ISO13485and ISO9001
In what areas TOC tests are routinely required?
Municipal Waste Water
Monitoring organic carbon of influent facilitates process controls for maximizing plant efficiency, while monitoring effluent is often a requirement for discharging into surface waters.
Industrial Waste Water
Industries which discharge liquid waste into a surface water body are required to monitor TOC.
Limiting potential sources of corrosive compounds can prevent costly damage to expensive equipment.
Water is the most commonly used ingredient in drug production. Regulations limit the concentration of organic carbon to prevent harmful microorganisms from growing.
Ultra-pure water is used in the manufacture of microprocessors and computer chips. As processors and circuits become smaller and smaller the water must be kept highly clean to prevent microscopic damage to these miniature circuits.
In the pharmaceutical industry, GMP production requires that the cleaning of drug manufacturing equipment/Medical device will be validated. Many different validation techniques can demonstrate that the manufacturing equipment is cleaned and essentially free from residual active drug substances and all cleaning agents.
TOC analysis can be adapted to any drug compound or cleaning agent that contains carbon. The method is sensitive to the ppb range and is less time consuming than HPLC or UV/Vis. USP TOC methods are standard for Water for Injection and Purified Water, and simple modifications of these methods can be used for cleaning validation.