Product: LNA & ZNA
LNA & ZNA
The locked nucleic acid (LNA) modification provides increased binding affinity and specificity to complementary nucleic acid sequences due to the rigid structure of the locked sugar moiety, which enhances base stacking and hydrophobic interactions. This property makes LNAs useful in a variety of applications, including gene expression analysis, SNP detection, and antisense therapeutics. Additionally, the increased thermal stability of LNA-containing oligonucleotides allows for more stringent hybridization conditions, leading to improved specificity and reduced background noise.
Zip Nucleic Acids (ZNA®) are another type of modified oligonucleotide. ZNA® technology appears to offer some advantages over unmodified oligonucleotides, such as higher affinity to their targets and the ability to modulate the Tm by adjusting the number of cationic spermine moieties. It could be useful for applications such as PCR and hybridization-based assays where target specificity and sensitivity are important.
In summary, both LNA and ZNA® modifications offer improved binding affinity and specificity to nucleic acid targets compared to unmodified oligonucleotides. LNA-containing oligonucleotides have increased thermal stability, while ZNA® technology offers the ability to modulate the Tm by adjusting the number of cationic spermine moieties. These properties make LNA and ZNA® oligonucleotides useful in a variety of applications, including gene expression analysis, SNP detection, and antisense therapeutics.