Very long oligos (40 up to 100 or more nucleotides) mainly used for the synthesis of artificial genes are extremely critical to production and purification conditions and protocols. Even if length and sequence reliability are unavoidably limited by standard phosporamidite chemistry and base composition (formation of secondary structures during synthesis!), synthesis success can effectively be influenced by using only top quality chemicals and instruments as well as constantly improving and optimizing the production process. Selected purification procedures based on carefully elaborated HPLC programs are the final key to metabion´s outstanding quality.

Large scale synthesis
We supply you with milligrams to tens of grams of the purest DNA available ("GMP quality") including both standard, and modified DNA , which is mainly required for antisense studies.